Search on: MITOGEN-ACTIVATED PROTEIN KINASE 1 
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Descriptor English:   Mitogen-Activated Protein Kinase 1 
Descriptor Spanish:   Proteína Quinasa 1 Activada por Mitógenos 
Descriptor Portuguese:   Proteína Quinase 1 Ativada por Mitógeno 
Synonyms English:   p42 MAPK
p42(Mitogen-Activated Protein Kinase)
Extracellular Signal-Regulated Kinase 2
p42 MAP Kinase
MAP Kinase 2
Mitogen-Activated Protein Kinase 2  
Tree Number:   D08.811.913.696.620.682.700.567.249.500
D12.644.360.450.169.500
D12.776.476.450.169.500
Definition English:   A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms. 
Indexing Annotation English:   Don't confuse MAP Kinase 2 with MAP KINASE KINASES referred to as MAP2 Kinases
History Note English:   2005(1992) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   33471 
Unique Identifier:   D019950 

Occurrence in VHL:
 

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